ALPPL2 is a member of the alkaline phosphatase (ALP) family. It is an enzyme protein that participates in intracellular phosphatase activity and plays an important role in cell signaling and metabolic processes. ALPPL2 is mainly expressed in human placental tissue and certain tumor cells. Its role in placental tissue includes the transfer of maternal immunoglobulin G (IgG) to the fetus, promotion of DNA synthesis and fibroblast cell proliferation in the presence of insulin, zinc ions, and calcium ions, as well as the synthesis of a tissue called syncytiotrophoblast cells, responsible for the transfer of nutrients and oxygen within the cell. Additionally, ALPPL2 may also serve as a marker for various cancers. The ALPPL2 gene is located on chromosome 2 and shares 87% similarity with the IAP gene. ALPPL2 is a polymorphic enzyme with up to 18 allelozymes originating from point mutations. Due to its low catalytic activity in the neutral pH of the placenta, it is considered to be inefficient. The structure of ALPPL2 includes two disulfide bonds, one stabilizing its orientation near the anchor of glycosylphosphatidylinositol (GPI) at Asp481, and the other reinforcing the anchor of the carbohydrate chain near the first part of glycosylation. Overall, ALPPL2 plays an important role within the cell, particularly in the physiological and pathological processes of placental tissue and cancer.

高纯度、高活性、低内毒素、高批间一致性。

SDS-PAGE

Figure 1. On SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%.

Bioactivity-ELISA

Figure 2. Human ALPPL2 Protein; His Tag was immobilized at 1 μg/ml (100 μL/well). Increasing concentrations of Anti-ALPPL2 mIgG2a antibody were added.

-85 ~ -65℃保存，收到货之日起，6个月有效期。避免反复冻融，建议等分分装为一次实验使用量，分装后，-80℃冻存。